![]() In the setting of low-dose aspirin for cardiac prophylaxis, monitor patients closely for GI bleeding.Īcute myocardial infarction, angina, cardiac arrhythmias, cardiac disease, cardiomyopathy, cerebrovascular disease, coronary artery bypass graft surgery (CABG), coronary artery disease, heart failure, hypertension, myocardial infarction, myocardial infarction or stroke, peripheral vascular disease, stroke, tachycardia, thromboembolism If a serious GI adverse event is suspected, promptly begin evaluation and treatment discontinue ibuprofen until a serious GI event is ruled out. Use the lowest effective dosage for the shortest possible duration, and avoid use of more than 1 NSAID at a time. ![]() Use this medication for the shortest effective duration and inform patients to promptly report signs and symptoms of GI ulcer or bleeding. Consider alternative (non-NSAID) therapy in at-risk patients. Most spontaneous reports of fatal GI reactions are in elderly or debilitated patients special care should be taken in treating this population. Use with caution in patients with other factors known to increase GI bleeding risk including: concomitant oral corticosteroid therapy, anticoagulant therapy, antiplatelet drug use (including low-dose aspirin), chemotherapy, longer duration of NSAID therapy, tobacco smoking, alcoholism or use of alcohol, older age, poor general health status, ulcerative colitis, or Crohn's disease. Therefore, use ibuprofen with caution, if at all, in patients with a history of or active GI disease, including peptic ulcer disease or GI bleeding. Serious and fatal GI adverse reactions including inflammation, bleeding, ulceration, and perforation of the stomach, small intestine, or large intestine have been reported in patients receiving NSAIDs. Alcoholism, anticoagulant therapy, chemotherapy, corticosteroid therapy, Crohn's disease, GI bleeding, GI disease, GI perforation, peptic ulcer disease, tobacco smoking, ulcerative colitisĬhronic use of ibuprofen can result in gastritis, ulceration with or without GI perforation, and/or GI bleeding, which can occur at any time, often without preceding symptoms.
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